Review Article

Year : 2019 | Volume : 3 | Issue : 1 | Page : 7 - 11

Review on cytochrome C

Anubhav Das

Department of Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, Tamil Nadu, India

Address for correspondence:

Dr. Anubhav Das, Department of Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, Tamil Nadu, India.

E‐mail: generalpath2015@gmail.com

Abstract

Cytochrome c (Cyt c) is an essential mitochondrial protein which takes part in the electron transport system and apoptosis. Cyt c also scavenges reactive oxygen species(ROS) and oxidizes cardiolipin during apoptosis. The recent finding that cyt c is phosphorylated in vivo for the important role of cyt c in the regulation of making life and death decisions. An apoptotic sequence of events takes place which involves changes in cyt c phosphorylation, increased ROS through increased mitochondrial membrane potentials, the oxidation of cardiolipin by cyt c, and its release from the mitochondria. Cyt c regulation in respiration and cellular death is discussed about human disease which includes neurodegenerative and cardiovascular diseases, cancer, and sepsis.

Keywords: Apoptosis, cancer, cardiolipin, cytochrome c, oxidative phosphorylation, reactive oxygen species

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

How to cite this article:

Das A. Review on cytochrome C. Int J Clinicopathol Correl 2019;3:7-11.