Review Article

Year : 2023 | Volume : 14 | Issue : 3 | Page : 1 - 10

The Effect of Melatonin and Its Agonist on Bone Metabolism: A Scoping Review

Sanjana Thiagarajan1 , Umarevathi Gopalakrishnan2 , Koduri Manoghna3 , R. Balasubramanian4 1,3,4 Post Graduate, 2Professor, Department of Orthodontics and Dentofacial Orthopaedics, Sri Venkateswara Dental College and Hospital, Thalambur, Chennai 600130, India.

Address for Correspondence:

Dr.Umarevathi Gopalakrishnan, MDS., Ph.D.

Professor, Department of Orthodontics and Dentofacial Orthopaedics Sri Venkateswara Dental College and Hospital, Thalambur, Chennai-600130.

Contact: +919841289794.

E-Mail: umarevathigopalakrishnan@gmail.com.

Abstract

Objectives:

To investigate the effects of melatonin and its agonist on bone tissue through a systematic review of literature.

Materials and Methods:

The keywords [Melatonin OR Pineal Hormone OR Ramelteon OR Agomelatine OR Tasimelteon] AND [Bone OR Osteoblast OR Osteoclast OR Bone remodelling OR Bone Metabolism] were searched on Scopus, Web of Science, and PubMed. Title and abstracts were reviewed to exclude the duplicates and irrelevant articles. The full-text articles were then screened in accordance with the inclusion criteria.

Results:

Of the 963 identified articles [PubMed=788, Web of Science=122, Scopus=53], only 3 studies qualified to be included in the systematic review based on the inclusion criteria. The first study assessed effects of the oral melatonin on bone integrity and mass in postmenopausal osteopenic women. Whereas the other two evaluated the radiographic and clinical outcomes of dental implants with the local application of melatonin. All studies showed an improved outcome parameter in comparison with the control group. All three studies elicited a low risk of bias.

Conclusion:

This study suggests that melatonin has osteoinductive potential and has an inhibitory effect on osteoclasts, thereby improving the quality and rate of bone remodelling.

Keywords: Melatonin, Bone remodelling, Pineal hormone, Osteoblast, Osteoclast, Orthodontics.

CONFLICT OF INTEREST

The authors declare no conflict of interest exist.

FUNDING

There are no funding agencies involved in the present study.

How to cite this article: Thiagarajan, S., Gopalakrishnan, U., Manoghna, K., & R, B. (2023). The Effect of Melatonin and Its Agonist on Bone Metabolism: A Scoping Review. International Journal of Orthodontic Rehabilitation, 14(3), 1–10. https://doi.org/10.56501/intjorthodrehabil.v14i3.826

Original Research

Year : 2023 | Volume : 14 | Issue : 2 | Page : 17-30

The Assessment of Palatal Rugae Characteristics in Different Malocclusions- A Scoping Review

Balasubramanian1 , Sanjana Thiagarajan2 , Manoghna Koduri3 , Uma Revathi Gopalakrishnan4 , Vidhya Selvaraj5

1,2,3 Post Graduate Student, 4Professor, 5Senior Lecturer, Department of Orthodontics and Dentofacial Orthopaedics, Sri Venkateswara Dental College and Hospital, Thalambur, Chennai-600130.

Address for Correspondence :

Sanjana T, MDS

Post graduate student, Department of Orthodontics and Dentofacial Orthopaedics Sri Venkateswara Dental College and Hospital, Thalambur, Chennai-600130, India. Email id: sanjanarajan.sr@gmail.com

Abstract

BACKGROUND

Early diagnosis of malocclusion and intercepting the malocclusion at an earlier stage is inevitable in orthodontics. The morphological characteristics of palatal rugae are set up at an early age and are stable in their position and pattern throughout the life of an individual, hence they are used as a reference landmark for superimposition and evaluate the extent of tooth movement in orthodontics. This review aims to analyze the orthodontic literature regarding the association of palatal rugae pattern with different malocclusion.

MATERIALS AND METHODS

To analyse the literature regarding the association of palatal rugae pattern with different malocclusion by using the keywords palatal rugae or plica palatine transversae or rugoscopy and malocclusion or sagittal malocclusion or class I or class II or class III or skeletal pattern and stability and orthodontics or orthodontia. The pubmed, Google scholar, Embase databases were searched till June 2022.

RESULTS

Wavy and Curved type of rugae was more common rugae pattern in all group of malocclusions. Many studies found there is no statistically significant difference in palatal rugae among malocclusion. However, few studies showing that largest number of rugae is present in class II malocclusion than class I and class III.

CONCLUSION

This review provides evidence of a distinct pattern of Palatal rugae in Class I and Class III malocclusion and largest number in Class II but to ascertain its statistical significance, further research is needed with a larger sample size.

KEYWORDS – Palatal Rugae, Malocclusion, Skeletal Pattern, Rugoscopy

SOURCE OF FUNDING

Nil in terms of financial assistance or sponsorship.

CONFLICT OF INTEREST

No conflicts of interest exist.

How to cite this article: Ramakrishnan, B., Thiagarajan, S., Manoghna, K., Gopalakrishnan, U. R., & selvaraj, V. (2023). The Assessment of Palatal Rugae Characteristics in Different Malocclusions- A Scoping Review : Original Research. International Journal of Orthodontic Rehabilitation, 14(2), 17–30. https://doi.org/10.56501/intjorthodrehabil.v14i2.611